New England Patriots @ Buffalo Bills: Preview, prediction and odds


Preview for New England Patriots @ Buffalo Bills

The New England Patriots travel to Buffalo this weekend for a Sunday Night Football showdown with the unbeaten Bills.

After edging the Miami Dolphins 33-27 in Week 2, the Patriots have the chance to open 2-0 in AFC East play for the first time since 2019.

The game also carries some extra history, as it will be New England’s final regular-season appearance at Highmark Stadium before Buffalo moves into its new venue next year.

This contest begins a difficult three-game road stretch for New England, with trips to New Orleans and Tennessee to follow. It’s the Patriots’ first run of three consecutive away fixtures since 2020.

The rivalry itself is one of the oldest in the AFC East, dating back to 1960. The Patriots hold a 79-51-1 advantage all-time, including a 37-26-1 record in Buffalo.

They’ve also thrived in prime-time matchups against the Bills, going 9-2 overall and a perfect 4-0 on Sunday Night Football. Last season the sides split their meetings, with Buffalo taking a 24-21 win in December before New England responded two weeks later with a 23-16 victory to close out the year.

Statistically, Buffalo has looked dominant in 2025, boasting the league’s second-ranked offense at 404 yards per game and averaging 33.3 points per outing.

The Patriots, meanwhile, sit at 2-2 but rank in the top ten in scoring at 25.5 points per game and have the NFL’s second-best rush defense, allowing just 77.5 yards on the ground per contest. Sunday’s clash will pit that defense against the Bills’ league-leading rushing attack, which averages 163.5 yards.

Several Patriots enter the game chasing personal milestones. Tight end Hunter Henry is within 79 yards of moving into fourth place among the franchise’s all-time receiving leaders at his position.

Running back Rhamondre Stevenson needs 59 rushing yards to climb into seventh on the team’s career list, while Antonio Gibson could join an exclusive group of Patriots with multiple kick-return touchdowns in a single season.

New England’s newest star receiver, Stefon Diggs, is looking to record back-to-back 100-yard games for the first time since 2023, when he was still a member of the Bills.

Rookie quarterback Drake Maye, meanwhile, has put together three straight games completing at least 75 percent of his passes with two touchdowns – a streak that could tie Tom Brady’s 2007 record if extended this weekend.

The Patriots’ offense has found rhythm in recent weeks, topping 40 points against Carolina last Sunday, but Buffalo’s combination of balance, depth, and defensive discipline makes this one of the sternest tests on their schedule.



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